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1

An efficient route to human bispecific IgG

Merchant, A. Margaret, Zhu, Zhenping, Yuan, Jean Q., Goddard, Audrey, Adams, Camellia W., Presta, Leonard G., Presta, Leonard G.

Journal:

Nature Biotechnology

Année:

1998

Fichier:

PDF, 653 KB

1998

2

‘Knobs-into-holes’ engineering of antibody C H 3 domains for heavy chain heterodimerization

Ridgway, John B.B., Presta, Leonard G., Carter, Paul

Journal:

Protein Engineering Design and Selection

Année:

1996

Langue:

english

Fichier:

PDF, 3.61 MB

english, 1996

3

Antibody engineering

Leonard G. Presta

Journal:

Current Opinion in Biotechnology

Année:

1992

Langue:

english

Fichier:

PDF, 496 KB

english, 1992

4

Engineering of therapeutic antibodies to minimize immunogenicity and optimize function

Leonard G. Presta

Journal:

Advanced Drug Delivery Reviews

Année:

2006

Langue:

english

Fichier:

PDF, 222 KB

english, 2006

5

ADAPTING PHARMACOKINETIC PROPERTIES OF A HUMANIZED ANTI-INTERLEUKIN-8 ANTIBODY FOR THERAPEUTIC APPLICATIONS USING SITE-SPECIFIC PEGYLATION

Steven R. Leong, Laura DeForge, Leonard Presta, Tania Gonzalez, Audrey Fan, Marcel Reichert, Anan Chuntharapai, K. Jin Kim, Daniel B. Tumas, Wyne Pun Lee, Peter Gribling, Brad Snedecor, Han Chen, Vane

Journal:

Année:

2001

Langue:

english

Fichier:

PDF, 414 KB

english, 2001

6

Isomerization of an Aspartic Acid Residue in the Complementarity-Determining Regions of a Recombinant Antibody to Human IgE: Identification and Effect on Binding Affinity

Cacia, Jerry, Keck, Rodney, Presta, Leonard G., Frenz, John

Journal:

Année:

1996

Langue:

english

Fichier:

PDF, 461 KB

english, 1996

7

Prediction of protein–ligand interactions: The complex of porcine pancreatic elastase with a valine-derived benzoxazinone

Leonard G. Presta, Edgar F. Meyer Jr.

Journal:

Année:

1987

Langue:

english

Fichier:

PDF, 996 KB

english, 1987

8

Remodeling domain interfaces to enhance heterodimer formation

Zhenping Zhu, Leonard G. Presta, Gerardo Zapata, Paul Carter

Journal:

Protein Science

Année:

1997

Langue:

english

Fichier:

PDF, 5.49 MB

english, 1997

9

Analysis of solvent structure in proteins using neutron D2OH2O solvent maps: Pattern of primary and secondary hydration of trypsin

Anthony A. Kossiakoff, Michael D. Sintchak, Joseph Shpungin, Leonard G. Presta

Journal:

Proteins: Structure, Function, and Bioinformatics

Année:

1992

Langue:

english

Fichier:

PDF, 1.26 MB

english, 1992

10

Mucosal addressin cell adhesion molecule-1 (MAdCAM-1)

Sherman Fong, Susan Jones, Mark E. Renz, Henry H. Chiu, Anne M. Ryan, Leonard G. Presta, David Jackson

Journal:

Immunologic Research

Année:

1997

Langue:

english

Fichier:

PDF, 1.17 MB

english, 1997

11

Humanization of a recombinant monoclonal antibody to produce a therapeutic HER dimerization inhibitor, pertuzumab

Camellia W. Adams, David E. Allison, Kelly Flagella, Leonard Presta, Janet Clarke, Noel Dybdal, Kathleen McKeever, Mark X. Sliwkowski

Journal:

Cancer Immunology, Immunotherapy

Année:

2006

Langue:

english

Fichier:

PDF, 390 KB

english, 2006

12

Molecular engineering and design of therapeutic antibodies

Leonard G Presta

Journal:

Current Opinion in Immunology

Année:

2008

Langue:

english

Fichier:

PDF, 386 KB

english, 2008

13

10.1038/74704

Ravetch, Jeffrey V., Clynes, Raphael A., Towers, Terri L., Presta, Leonard G.

Journal:

Nature Medicine

Année:

2000

Langue:

english

Fichier:

PDF, 196 KB

english, 2000

14

Evolving an anti-toxin antibody

Presta, Leonard

Journal:

Nature Biotechnology

Année:

2007

Langue:

english

Fichier:

PDF, 510 KB

english, 2007

15

Celebrating diversity and mimicking maturation

Presta, Leonard G.

Journal:

Nature Biotechnology

Année:

2002

Langue:

english

Fichier:

PDF, 134 KB

english, 2002

16

Antigen binding thermodynamics and antiproliferative effects of chimeric and humanized anti-p185HER2 antibody Fab fragments

Kelley, Robert F., O'Connell, Mark P., Carter, Paul, Presta, Leonard, Eigenbrot, Charles, Covarrubias, Michael, Snedecor, Brad, Bourell, James H., Vetterlein, David

Journal:

Année:

1992

Langue:

english

Fichier:

PDF, 1.55 MB

english, 1992

17

Antibody engineering

Leonard G Presta

Journal:

Current Biology

Année:

1992

Langue:

english

Fichier:

PDF, 129 KB

english, 1992

18

Simple quantitative live cell and anti-idiotypic antibody based ELISA for humanized antibody directed to cell surface protein CD20

Kyu Hong, Leonard G. Presta, Yanmei Lu, Ashley Penn, Camellia Adams, Anan Chuntharapai, Jihong Yang, Wai Lee Wong, Y. Gloria Meng

Journal:

Journal of Immunological Methods

Année:

2004

Langue:

english

Fichier:

PDF, 149 KB

english, 2004

19

Identification of IgG1 variants with increased affinity to FcγRIIIa and unaltered affinity to FcγRI and FcRn: Comparison of soluble receptor-based and cell-based binding assays

Yanmei Lu, Jean-Michel Vernes, Nancy Chiang, Qinglin Ou, Jiabing Ding, Camellia Adams, Kyu Hong, Bao-Tran Truong, Domingos Ng, Amy Shen, Gerald Nakamura, Qian Gong, Leonard G. Presta, Maureen Beresini

Journal:

Journal of Immunological Methods

Année:

2011

Langue:

english

Fichier:

PDF, 466 KB

english, 2011

20

Antibody engineering for therapeutics

Journal:

Current Opinion in Structural Biology

Année:

2003

Langue:

english

Fichier:

PDF, 181 KB

english, 2003

21

CHARACTERIZATION AND HUMANIZATION OF A MONOCLONAL ANTIBODY THAT NEUTRALIZES HUMAN LEUKOCYTE INTERFERON: A CANDIDATE THERAPEUTIC FOR IDDM AND SLE

Anan Chuntharapai, Jadine Lai, Xiaojian Huang, Verna Gibbs, K.Jin Kim, Leonard G. Presta, Timothy A. Stewart

Journal:

Année:

2001

Langue:

english

Fichier:

PDF, 301 KB

english, 2001

22

X-ray Structures of the Antigen-binding Domains from Three Variants of Humanized anti-p185HER2 Antibody 4D5 and Comparison with Molecular Modeling

Charles Eigenbrot, Michael Randal, Leonard Presta, Paul Carter, Anthony A. Kossiakoff

Journal:

Journal of Molecular Biology

Année:

1993

Fichier:

PDF, 1.78 MB

1993

23

The 1.85 Å resolution crystal structures of tissue factor in complex with humanized fab d3h44 and of free humanized fab d3h44: revisiting the solvation of antigen combining sites

Katja Faelber, Daniel Kirchhofer, Leonard Presta, Robert F Kelley, Yves A Muller

Journal:

Journal of Molecular Biology

Année:

2001

Langue:

english

Fichier:

PDF, 701 KB

english, 2001

24

Hydrogen bonding in globular proteins

Douglas F. Sticke, Leonard G. Presta, Ken A. Dill, George D. Rose

Journal:

Journal of Molecular Biology

Année:

1992

Langue:

english

Fichier:

PDF, 1.79 MB

english, 1992

25

Comprehensive Functional Maps of the Antigen-binding Site of an Anti-ErbB2 Antibody Obtained with Shotgun Scanning Mutagenesis

Felix F Vajdos, Camellia W Adams, Timothy N Breece, Leonard G Presta, Abraham M de Vos, Sachdev S Sidhu

Journal:

Journal of Molecular Biology

Année:

2002

Langue:

english

Fichier:

PDF, 345 KB

english, 2002

26

Structural Insight into How An Anti-idiotypic Antibody Against D3H44 (Anti-tissue Factor Antibody) Restores Normal Coagulation

Charles Eigenbrot, Y.Gloria Meng, Rajeswari Krishnamurthy, Michael T. Lipari, Leonard Presta, Brigitte Devaux, Terence Wong, Paul Moran, Sherron Bullens, Daniel Kirchhofer

Journal:

Journal of Molecular Biology

Année:

2003

Langue:

english

Fichier:

PDF, 2.35 MB

english, 2003

27

Selection, design, and engineering of therapeutic antibodies

Presta, Leonard G.

Journal:

Journal of Allergy and Clinical Immunology

Année:

2005

Langue:

english

Fichier:

PDF, 123 KB

english, 2005

28

Antibody engineering

Presta, Leonard G.

Journal:

Current Opinion in Structural Biology

Année:

1992

Langue:

english

Fichier:

PDF, 466 KB

english, 1992

29

Structural Requirements for Adhesion of Soluble Recombinant Murine Vascular Cell Adhesion Molecule-1 to α4β1

Mark E. Renz, Henry H. Chiu, Susan Jones, Judy Fox, K. Jin Kim, Leonard G. Presta and Sherman Fong

Journal:

The Journal of Cell Biology

Année:

1994

Langue:

english

Fichier:

PDF, 2.54 MB

english, 1994

30

Identification of an E-Selectin Region Critical for Carbohydrate Recognition and Cell Adhesion

David V. Erbe, Barry A. Wolitzky, Leonard G. Presta, Christine R. Norton, Robert J. Ramos, Daniel K. Burns, John M. Rumberger, B. N. Narasinga Rao, Carrol Foxall, Brian K. Brandley and Laurence A. Las

Journal:

The Journal of Cell Biology

Année:

1992

Langue:

english

Fichier:

PDF, 3.50 MB

english, 1992

31

P- and E-Selectin Use Common Sites for Carbohydrate Ligand Recognition and Cell Adhesion

David V. Erbe, Susan R. Watson, Leonard G. Presta, Barry A. Wolitzky, Carroll Foxall, Brian K. Brandley and Laurence A. Lasky

Journal:

The Journal of Cell Biology

Année:

1993

Langue:

english

Fichier:

PDF, 721 KB

english, 1993

32

Specificity Determinants in Neurotrophin-3 and Design of Nerve Growth Factor-Based trkC Agonists by Changing Central β-Strand Bundle Residues to Their Neurotrophin-3 Analogs †

Urfer, Roman, Tsoulfas, Pantelis, O'Connell, Lori, Presta, Leonard G.

Journal:

Année:

1997

Langue:

english

Fichier:

PDF, 168 KB

english, 1997

33

Stereospecific reaction of 3-methoxy-4-chloro-7-aminoisocoumarin with crystalline porcine pancreatic elastase

Meyer, Edgar F., Presta, Leonard G., Radhakrishnan, R.

Journal:

Journal of the American Chemical Society

Année:

1985

Langue:

english

Fichier:

PDF, 366 KB

english, 1985

34

Contribution to Global Protein Stabilization of the N-Capping Box in Human Growth Hormone

Zhukovsky, Eugene A., Mulkerrin, Michael G., Presta, Leonard G.

Journal:

Année:

1994

Langue:

english

Fichier:

PDF, 1.90 MB

english, 1994

35

Inhibition of Allergic Reactions with Antibodies to IgE

Shields, Robert L., Whether, Winifred R., Zioncheck, Kimberly, O&rsquo, Connell, Lori, Fendly, Brian, Presta, Leonard G., Thomas, Deborah, Saban, Ricardo, Jardieu, Paula

Journal:

International Archives of Allergy and Immunology

Année:

1995

Fichier:

PDF, 1.95 MB

1995

36

Mutational analysis and molecular modeling of the N-terminal kringle-containing domain of hepatocyte growth factor identifies amino acid side chains important for interaction with the c-Metreceptor

Lokker, Nathalie A., Presta, Leonard G., Godowski, Paul J.

Journal:

Protein Engineering Design and Selection

Année:

1994

Langue:

english

Fichier:

PDF, 5.16 MB

english, 1994

37

Protein structure analysis and development of databases

Presta, Leonard

Journal:

Protein Engineering Design and Selection

Année:

1989

Langue:

english

Fichier:

PDF, 295 KB

english, 1989

38

Engineering Antibodies for Therapy

Presta, Leonard

Journal:

Current Pharmaceutical Biotechnology

Année:

2002

Langue:

english

Fichier:

PDF, 199 KB

english, 2002

39

Mapping the CD4 Binding Site for Human Immunodeficiency Virus by Alanine- Scanning Mutagenesis

Avi Ashkenazi, Leonard G. Presta, Scot A. Marsters, Thomas R. Camerato, Kim A. Rosenthal, Brian M. Fendly and Daniel J. Capon

Journal:

Proceedings of the National Academy of Sciences

Année:

1990

Langue:

english

Fichier:

PDF, 1.15 MB

english, 1990

40

[Annual Reports in Medicinal Chemistry] Volume 29 || Chapter 32. Humanized Monoclonal Antibodies

Presta, Leonard

Année:

1994

Langue:

english

Fichier:

PDF, 1.33 MB

english, 1994

41

Anti-lgE Monoclonal Antibodies that Inhibit Allergen-Specific Histamine Release

Shields, Robert L., Werther, Winifred R., Zioncheck, Kimberly, O’Connell, Lori, Klassen, Toni, Fendly, Brian, Presta, Leonard G., Jardieu, Paula M.

Journal:

International Archives of Allergy and Immunology

Année:

1995

Langue:

english

Fichier:

PDF, 399 KB

english, 1995

42

Generation of a Humanized, High Affinity Anti-tissue Factor Antibody for Use as a Novel Antithrombotic Therapeutic

Presta, Leonard, Sims, Paul, Meng, Y. Gloria, Moran, Paul, Bullens, Sherron, Bunting, Stuart, Schoenfeld, Jill, Lowe, David, Lai, Jadine, Rancatore, Patricia, Iverson, Mark, Lim, Amy, Chisholm, Vaness

Journal:

Thrombosis and Haemostasis

Année:

2001

Langue:

english

Fichier:

PDF, 490 KB

english, 2001